“胚胎膠” 有用嗎？

 

Does embryo glue really work?

It sounded too good to be true. 

Implantation is a multi-stage process which includes zona pellucida hatching, apposition and adhesion of blastocyst followed by an invasion of trophoblast into the uterine endometrium.  One of the reasons for unsuccessful implantation being failure to develop a sticky matrix between blastocyst and endometrium. Various modifications have been made in embryo transfer  medium to improve implantation and pregnancy rates. Protein supplementation has been widely used in embryo transfer medium, most common of which is albumin.

Hyaluronan (HA) occurs naturally in your uterus, fallopian tubes and ovaries. It makes these organs stickier, aiding fertilization and implantation. Embryo glue mimics those uterine secretions. Embryo glue is a medium, which contains high concentration of hyaluronan and low concentration of recombinant human albumin.  On your embryo transfer day, your embryos are dipped into the ‘glue’. Then they’re placed in your uterus. The adhesive effect of the medium may help your embryos stick to your endometrium.

Simple idea. Good name.

Despite its name, embryo glue isn’t really a glue at all. It’s a specially developed solution that contains, high levels of a substance called hyaluronan. We would rather call that implantation-friendly.  Whether or not the embryo REALLY implants, love to stay in the uterus, still depends on the embryo.

The success stories about embryo glue are encouraging. As we know, there is no adverse effect on IVF results with embryo glue.  Not bad to have a try!